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Academic Article
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Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways.
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Academic Article
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JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
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Academic Article
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Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
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Academic Article
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Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
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Academic Article
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Identification of interleukin-2 receptor-associated tyrosine kinase p116 as novel leukocyte-specific Janus kinase.
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Academic Article
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Structural domains of interleukin-2 receptor beta critical for signal transduction: kinase association and nuclear complex-formation.
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Academic Article
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Interleukin-13 is a potent activator of JAK3 and STAT6 in cells expressing interleukin-2 receptor-gamma and interleukin-4 receptor-alpha.
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Academic Article
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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
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Academic Article
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Differential regulation of the Janus kinase-STAT pathway and biologic function of IL-13 in primary human NK and T cells: a comparative study with IL-4.
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Academic Article
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Mechanisms of cytokine signal transduction: IL-2, IL-4 and prolactin as hematopoietin receptor models.
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Academic Article
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Tyrphostin AG-490 inhibits cytokine-mediated JAK3/STAT5a/b signal transduction and cellular proliferation of antigen-activated human T cells.
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Academic Article
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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
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Academic Article
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Molecular actions of sirolimus: sirolimus and mTor.
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Academic Article
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Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells.
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Academic Article
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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
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Academic Article
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Involvement of the ubiquitin-proteasome pathway in the degradation of nontyrosine kinase-type cytokine receptors of IL-9, IL-2, and erythropoietin.
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Academic Article
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Allochimeric class I MHC protein-induced tolerance by partial TCR engagement requires activation of both CTL4- and common gamma-chain-dependent cytokine signals.
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Academic Article
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Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.
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Academic Article
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Regulation of lymphoid cell apoptosis by Jaks and Stats.
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Academic Article
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Activation of JAK3, but not JAK1, is critical to interleukin-4 (IL4) stimulated proliferation and requires a membrane-proximal region of IL4 receptor alpha.
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Academic Article
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Janus tyrosine kinases and signal transducers and activators of transcription regulate critical functions of T cells in allograft rejection and transplantation tolerance.
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Academic Article
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Involvement of JAK-family tyrosine kinases in hematopoietin receptor signal transduction.
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Academic Article
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Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
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Academic Article
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Growth signaling and JAK2 association mediated by membrane-proximal cytoplasmic regions of prolactin receptors.
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Academic Article
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Activation of JAK3, but not JAK1, is critical for IL-2-induced proliferation and STAT5 recruitment by a COOH-terminal region of the IL-2 receptor beta-chain.
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Academic Article
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Regulation of T cell homeostasis by JAKs and STATs.
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Academic Article
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The PHB1/2 phosphocomplex is required for mitochondrial homeostasis and survival of human T cells.
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Academic Article
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Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
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Academic Article
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STAT3: an important regulator of multiple cytokine functions.
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Academic Article
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STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
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Academic Article
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Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
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Academic Article
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Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells.
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Concept
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Signal Transduction
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Academic Article
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Identification of a Stat-6-responsive element in the promoter of the human interleukin-4 gene.
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Academic Article
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The Many Faces of JAKs and STATs Within the COVID-19 Storm.
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Academic Article
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Phosphorylation of CrkL S114 induced by common gamma chain cytokines and T-cell receptor signal transduction.
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Academic Article
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Identification of a Potent Cytotoxic Pyrazole with Anti-Breast Cancer Activity That Alters Multiple Pathways.
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Academic Article
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JAK1 Pseudokinase V666G Mutant Dominantly Impairs JAK3 Phosphorylation and IL-2 Signaling.
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Academic Article
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JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
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